246pa Meta-analysis of Biomarkers in Three Randomized, Phase 2 Studies of Mm-121, a Ligand-blocking Anti-erbb3 Antibody, in Patients with Ovarian, Lung, and Breast Cancers.
نویسندگان
چکیده
G. Macbeath1, B. Adiwijaya1, J. Liu2, L.V. Sequist3, E. Pujade-Lauraine5, M. Higgins3, I. Tabah-Fisch5, J. Pearlberg6, V. Moyo7, W. Kubasek1, R. Nering8, A. Czibere8 Translational Research and Discovery, Merrimack Pharmaceuticals, Cambridge, MA, USA Gynecologic Oncology Program, Dana Farber Cancer Institute, Boston, MA, USA Hematology/oncology, Massachusetts General Hospital, Boston, MA, USA CHU Paris Centre Hôpital Hôtel-dieu, CHU Paris Centre Hôpital Hôtel-Dieu, Paris, FRANCE Sanofi Oncology, Sanofi, Paris, FRANCE Sanofi Oncology, Sanofi, Cambridge, MA, USA Discovery, Merrimack Pharmaceuticals, Cambridge, MA, USA Clinical Development, Merrimack Pharmaceuticals, Cambridge, MA, USA
منابع مشابه
An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation.
ErbB3 is a critical activator of phosphoinositide 3-kinase (PI3K) signaling in epidermal growth factor receptor (EGFR; ErbB1), ErbB2 [human epidermal growth factor receptor 2 (HER2)], and [hepatocyte growth factor receptor (MET)] addicted cancers, and reactivation of ErbB3 is a prominent method for cancers to become resistant to ErbB inhibitors. In this study, we evaluated the in vivo efficacy ...
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ورودعنوان ژورنال:
- Annals of oncology : official journal of the European Society for Medical Oncology
دوره 25 suppl_4 شماره
صفحات -
تاریخ انتشار 2014