246pa Meta-analysis of Biomarkers in Three Randomized, Phase 2 Studies of Mm-121, a Ligand-blocking Anti-erbb3 Antibody, in Patients with Ovarian, Lung, and Breast Cancers.

نویسندگان

  • G Macbeath
  • B Adiwijaya
  • J Liu
  • L V Sequist
  • E Pujade-Lauraine
  • M Higgins
  • I Tabah-Fisch
  • J Pearlberg
  • V Moyo
  • W Kubasek
  • R Nering
  • A Czibere
چکیده

G. Macbeath1, B. Adiwijaya1, J. Liu2, L.V. Sequist3, E. Pujade-Lauraine5, M. Higgins3, I. Tabah-Fisch5, J. Pearlberg6, V. Moyo7, W. Kubasek1, R. Nering8, A. Czibere8 Translational Research and Discovery, Merrimack Pharmaceuticals, Cambridge, MA, USA Gynecologic Oncology Program, Dana Farber Cancer Institute, Boston, MA, USA Hematology/oncology, Massachusetts General Hospital, Boston, MA, USA CHU Paris Centre Hôpital Hôtel-dieu, CHU Paris Centre Hôpital Hôtel-Dieu, Paris, FRANCE Sanofi Oncology, Sanofi, Paris, FRANCE Sanofi Oncology, Sanofi, Cambridge, MA, USA Discovery, Merrimack Pharmaceuticals, Cambridge, MA, USA Clinical Development, Merrimack Pharmaceuticals, Cambridge, MA, USA

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation.

ErbB3 is a critical activator of phosphoinositide 3-kinase (PI3K) signaling in epidermal growth factor receptor (EGFR; ErbB1), ErbB2 [human epidermal growth factor receptor 2 (HER2)], and [hepatocyte growth factor receptor (MET)] addicted cancers, and reactivation of ErbB3 is a prominent method for cancers to become resistant to ErbB inhibitors. In this study, we evaluated the in vivo efficacy ...

متن کامل

144 Alterations in Apoptosis-related Genes in Cell Line Models of Acquired Lapatinib Resistance, Identifies Potential Therapeutic Targets for the Treatment of Lapatinib Resistant HER2-positive Breast Cancer

activation of ErbB3 and to sensitize platinum-resistant cells to subsequent chemotherapy. Materials and Methods: Cisplatin-sensitive (A2780) and -resistant (A2780cis) ovarian cancer cell lines were acquired from ATCC. Primary ascites cells were isolated from advanced stage ovarian cancer patients who had undergone prior therapy. Cells were propagated in vitro and cell viability assays were perf...

متن کامل

Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model.

Heregulin-driven ERBB3 signaling has been implicated as a mechanism of resistance to cytotoxic and antiendocrine therapies in preclinical breast cancer models. In this study, we evaluated the effects of seribantumab (MM-121), a heregulin-blocking anti-ERBB3 monoclonal antibody, alone and in combination with the aromatase inhibitor letrozole, on cell signaling and tumor growth in a preclinical m...

متن کامل

P-158: ART and Gynecological Cancer: Report of Our Experiences and Literature Review

Background: Infertility is an important and common problem in couples that needs to assisted reproductive technology (ART) or the other drug therapies. Infertility has been known as a risk factor for ovarian cancer, breast cancer and endometrial cancer but there is a question about the relationship of these cancers to infertility itself or drugs and methods of infertility treatment. Materials a...

متن کامل

The safety and effectiveness of the current treatment regimen with or without roflumilast in advanced COPD patients: A systematic review and meta-analysis of randomized controlled trials

  Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease, which reduces the lung function and causes respiratory symptoms over time, and it is primarily associated with shortness of breath, cough and sputum production. Roflumilast, which is a long-acting selective inhibitor, reduces the anti-inflammatory effect of the main symptoms of COPD. The aim of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Annals of oncology : official journal of the European Society for Medical Oncology

دوره 25 suppl_4  شماره 

صفحات  -

تاریخ انتشار 2014